1: Fully sequenced human genome When Karen MIGA, a genomics researcher at the University of California Santa Cruz, and Adam phillippy of the National Human Genome Institute in Bethesda, Maryland, launched the telomere telomere (T2T) alliance in 2019, about one tenth of the human genome was still unknown. Now, this number has fallen to zero. In a preprint published last May, the alliance reported the first end-to-end sequence of the human genome, adding nearly 200million new base pairs to the widely used human common genome sequence called grch38, and wrote the last chapter of the human genome project. Grch38, first released in 2013, has always been a valuable sequence tool, but due to the short reading, it is not enough to clearly map the highly repetitive genome sequence, including telomeres and centromeres that coordinate the distribution of newly replicated DN...

CRISPR gene editing has made a major breakthrough. Intelligent therapeutics and regeneron jointly announced that the in vivo gene editing therapy ntla-2001 jointly developed by them not only significantly reduces the level of pathogenic proteins in patients after one treatment, but also shows good safety.Professor Jennifer doudna, the co-founder of intellia therapeutics and a pioneer in the field of CRISPR gene editing and the winner of the 2020 Nobel Prize in chemistry, said that CRISPR gene editing took less than 10 years from the initial basic scientific discovery to transformation into clinical research. In her memory, this is one of the fastest transformation technologies.Where will CRISPR gene editing go in the future? Now let's take a look at the insights shared by Professor Jennifer doudna in the recent interview and the layout of intellia. Jenn...

Cutting edge scientific progress lies in the biological world Since the birth of crispr-cas9 gene editing technology, people have been so impressed with its nickname "gene magic scissors" that they have neglected that it can also be used as a tool for gene expression enhancement and gene expression reduction.Qi Lei of Stanford University was the first to develop crispr-dcas9 and apply it to gene expression enhancement (crispra) and gene expression reduction (crispri). This technology can accurately regulate gene expression without causing DNA double strand breaks, which also greatly expands the application scope and potential of CRISPR technology.On June 24, 2021, Qi Yiping's team from the University of Maryland published a research paper entitled CRISPR – act3.0 for highly efficient multiplex gene activation in plants in nature plants.The research deve...

With the progress of biotechnology and its penetration into other fields, a global revolution is moving towards bioeconomy. All major economic powers in the world regard biological manufacturing as a national strategy to ensure economic development, energy security and environmental friendliness, promote the formation of a strategic industrial system coordinated with the environment, and seize the competitive commanding height of the future biological economy.The continuous support of national policies will create a good external environment for industrial developmentThe capital market pays great attention to the biological fermentation industry, which enhances the driving force of sustainable developmentChanges in consumer market demand bring vitality to the development of biological fermentation industryDuring the "12th Five Year Plan" period, the biological fermentation indus...